The WHO warns that antibiotic resistance may become the number one killer of global health

Key discovery
The number of countries with high drug resistance rates has increased: Among the 114 countries monitored by the WHO, 75% reported that the resistance rate of common bacteria (such as Escherichia coli and Klebsiella pneumoniae) to first-line antibiotics exceeded 50%, and the situation was particularly severe in some low - and middle-income countries.

The spread of "super fungi" : Multidrug-resistant Candida auris has broken out in more than 40 countries, with a drug resistance of up to 90% to existing antifungal drugs and a mortality rate of up to 60% among severe patients.

Pressure on the medical system: Common surgeries (such as cesarean sections and joint replacements) and chemotherapy have seen a sharp increase in risks due to the failure of antibiotics, potentially reverting to the "pre-antibiotic era".

Reasons and Challenges
Abuse and misuse: In some countries, antibiotics can be purchased without a prescription, and the problem of excessive use in the agricultural sector is prominent.

Research and development stagnation: In the past 30 years, only two new antibiotics have been launched on the market, and pharmaceutical companies have withdrawn from research and development due to low profits.

Inequality issue: In some parts of Africa, the testing capacity is insufficient, and the actual drug resistance data may be underestimated.

Global response measures
The WHO calls on all countries to implement the National Action Plan on Antibiotic Resistance and proposes:

"One Health" Initiative: Coordinating the regulation of antibiotic use in the human, animal and environmental domains.

Innovation Fund: G20 countries have committed to investing 500 million US dollars to support the research and development of new antibiotics.

Public education: China, India and other countries have launched publicity campaigns on "Rational Use of Antibiotics".